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Beilstein J. Org. Chem. 2011, 7, 1486–1493, doi:10.3762/bjoc.7.172
Graphical Abstract
Scheme 1: Proline-catalyzed direct enantioselective α-aminoxylation of aldehydes.
Figure 1: Polystyrene-immobilized hydroxyproline 1a.
Scheme 2: Preparation of the immobilized catalysts 1a and 1b.
Scheme 3: Direct enantioselective α-aminoxylation of propanal catalyzed by resins 1a and 1b.
Figure 2: Experimental setup for the continuous-flow α-aminoxylation of aldehydes.